Smithville is located on Regional Road 20 between Hamilton and Niagara Falls. It is also situated along the Twenty Mile Creek, which played an important role in the town’s early development.
One of the town's first settlers was Richard Griffin and his family who came from New York State in 1787 and settled on Lots 8, 9 and 10, Concession IX along the Twenty. The daughter of Richard Griffin married Solomon Hill and they took up a residence close by along with the families of Thomas Harris and Thomas North.
This settlement would become known as Griffintown. Later the settlement would be renamed Smithville after Richard Griffins wife Mary whose maiden name was Smith. Smithville is well known for its numerous poultry farms.
A Farmers Market operates every Saturday morning in the summer months. Smithville holds an annual fair every year on the Labour Day Weekend.